Pathogenesis and clinical consequences of iron overload in chronic hepatitis C - impact of
نویسندگان
چکیده
Chronic hepatitis C virus infection is a leading cause of progressive liver fibrosis, liver cirrhosis and hepatocellular carcinoma. Iron overload is frequently observed in cases of chronic hepatitis C and has been suggested as a negative prognostic factor for this disease. Although the mechanisms leading to iron accumulation are not fully explained yet, both host and viral factors seem to contribute towards the development of this pathology. Better understanding of the interplay between hepatitis C virus replication and expression of iron regulatory molecules may elucidate new and interesting targets for the effective treatment of chronic hepatitis C.
منابع مشابه
Assessment Hepatomegaly and liver Enzymesin 100 Patients with beta Thalassemia Major in Mashhad, Iran
Abstract Background Frequent blood transfusion in patients with beta thalassemia major can lead to iron overload especially in liver. Chronic iron overload could cause cirrhosis of the liver. Transfusion- transmitted hepatitis B and C also could develop cirrhosis in individuals. Materials and Methods The present cross- sectional descriptive study is to assess hepatomegaly and liver enzymes ...
متن کاملEndocrine-Manifestations of Cirrhosis and Liver Disease
The liver is involved in the synthesis and metabolism of many kinds of hormones, various abnormalities hormone levels are found in advanced liver disease. For example the liver is, extremely sensitive to changes in insulin or glucagon levels. The liver is the primary organ of iron storage is frequently involved, diabetes is common in patients with iron overload and may be seen in cirrhosis. Chr...
متن کاملIron Overload and Hepatitis C Virus Infection
To the Editor: We read with interest the review by Zou and Sun on the iron accumulation linked to hepatitis C virus (HCV) infection.[1] Whichever the mechanism for the overload, we would like to emphasize the important medical consequences of such accumulation; these encompass not only a worse prognosis of chronic hepatitis but also a higher risk of hepatocellular carcinoma (HCC),[1] Type 2 dia...
متن کاملIron overload in patients with chronic hepatitis C virus infection: clinical and histological study.
BACKGROUND Recently it has been found that iron is an important element in the natural history of hepatitis C. Serum markers of iron stores are frequently increased in chronic hepatitis C virus (HCV)-infected carriers but the real impact of the hepatic iron overload is poorly understood. The purpose of the present paper was to determine the prevalence of iron overload and to study the relations...
متن کاملEffects of dietary iron reduction versus phlebotomy in patients with chronic hepatitis C: results from a randomized, controlled trial on 40 Japanese patients.
BACKGROUND AND AIM Iron may play an important role in the pathogenesis of hepatitis C. We conducted this randomized, controlled trial comparing phlebotomy with dietary iron reduction. METHODS Forty patients with chronic hepatitis C showing serum ferritin levels of over 150 ng/ml were randomized to either group A (low-iron diet for six months) or group B (phlebotomy biweekly). Phlebotomy was c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011